2. Academic Validation
  3. Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents

Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents

  • J Med Chem. 2003 Jul 3;46(14):2813-5. doi: 10.1021/jm030213+.
Srinivas K Kumar 1,  Erin Hager,  Catherine Pettit,  Hallur Gurulingappa,  Nancy E Davidson,  Saeed R Khan
Affiliations

Affiliation

  • 1 Division of Experimental Therapeutics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.
PMID: 12825923 DOI: 10.1021/jm030213+
Abstract

A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast Cancer cell lines. The results show the boronic-chalcones are more toxic to breast Cancer cells compared to normal breast cells than Other known Chalcones.

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