2. Academic Validation
  3. Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives

Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives

  • Bioorg Med Chem Lett. 2003 Sep 15;13(18):3001-4. doi: 10.1016/s0960-894x(03)00634-6.
Kenji Matsuno 1,  Takashi Seishi,  Takao Nakajima,  Michio Ichimura,  Neill A Giese,  Jin-Chen Yu,  Shoji Oda,  Yuji Nomoto
Affiliations

Affiliation

  • 1 Kyowa Hakko Kogyo Co., Ltd., Pharmaceutical Research Institute, Shimotogari 1188, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, Japan. [email protected]
PMID: 12941321 DOI: 10.1016/s0960-894x(03)00634-6
Abstract

Here, we investigated the structure-activity relationships of the 6,7-dimethoxyquinazoline moiety. With regard to exploration of positions and varieties of substituents on the quinazoline ring, 6,7-dialkoxy substitution was optimal. This study suggests the possibility of further modifications for this moiety.

Figures