2. Academic Validation
  3. Mapping the kinase domain of Janus Kinase 3

Mapping the kinase domain of Janus Kinase 3

  • Bioorg Med Chem Lett. 2003 Sep 15;13(18):3105-10. doi: 10.1016/s0960-894x(03)00657-7.
Christopher Adams 1,  David J Aldous,  Shelley Amendola,  Paul Bamborough,  Colin Bright,  Sarah Crowe,  Paul Eastwood,  Garry Fenton,  Martyn Foster,  Trevor K P Harrison,  Sue King,  Justine Lai,  Christopher Lawrence,  Jean-Philippe Letallec,  Clive McCarthy,  Neil Moorcroft,  Kenneth Page,  Sudha Rao,  Jane Redford,  Shazia Sadiq,  Keith Smith,  John E Souness,  Sukanthini Thurairatnam,  Mark Vine,  Barry Wyman
Affiliations

Affiliation

  • 1 Aventis Pharmaceuticals, 1041 Route 202-206, PO Box 6800, Bridgewater, NJ 08807, USA.
PMID: 12941344 DOI: 10.1016/s0960-894x(03)00657-7
Abstract

The utilization and impact of parallel synthesis on lead exploration around initial hit oxindole (1) are described. The emergent SAR, analogue design and functional impact will also be detailed.

Figures