2. Academic Validation
  3. Excellent enantio-selective enclathration of (2R,3S)-3-methyl-2-pentanol in channel-like cavity of 3-epideoxycholic acid, interpreted by the four-location model for chiral recognition

Excellent enantio-selective enclathration of (2R,3S)-3-methyl-2-pentanol in channel-like cavity of 3-epideoxycholic acid, interpreted by the four-location model for chiral recognition

  • Chem Commun (Camb). 2003 Dec 7:(23):2872-3. doi: 10.1039/b309755b.
Kazuaki Kato 1,  Kazuaki Aburaya,  Yasuhito Miyake,  Kazuki Sada,  Norimitsu Tohnai,  Mikiji Miyata
Affiliations

Affiliation

  • 1 Department of Material anld Life Science, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. [email protected]
PMID: 14680217 DOI: 10.1039/b309755b
Abstract

Pure (2R,3S)-3-methyl-2-pentanol is resolved from the racemates by a steroidal host; the interpretation of the recognition mechanism based on the crystal structure reveals that CH/O interaction between the host and guest plays a decisive role in enantio-selective enclathration of the small aliphatic secondary alcohol.

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