2. Academic Validation
  3. Cytotoxic flavonoids and alpha-pyrones from Cryptocarya obovata

Cytotoxic flavonoids and alpha-pyrones from Cryptocarya obovata

  • J Nat Prod. 2004 May;67(5):858-62. doi: 10.1021/np030510h.
Vincent Dumontet 1,  Nguyen Van Hung,  Marie-Thérèse Adeline,  Claude Riche,  Angèle Chiaroni,  Thierry Sévenet,  Françoise Guéritte
Affiliations

Affiliation

  • 1 Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
PMID: 15165150 DOI: 10.1021/np030510h
Abstract

One alpha-pyrone, obolactone (1), two Chalcones, kurzichalcolactone B (2) and obochalcolactone (3), and two flavanones, oboflavanones A (4) and B (5), have been isolated from the fruits and the trunk bark of Cryptocarya obovata. The structures of the new compounds were elucidated by spectroscopic interpretations. The absolute configuration of obolactone (1) was established by circular dichroism. Obolactone (1) and obochalcolactone (3) display significant activity in in vitro cytotoxic assays against the KB cell line. Biosynthetic pathways for oboflavanones and obochalcolactone are suggested.

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