2. Academic Validation
  3. Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity

Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity

  • Bioorg Med Chem Lett. 2004 Oct 4;14(19):4907-9. doi: 10.1016/j.bmcl.2004.07.036.
Ahmed Kamal 1,  R Ramu,  G B Ramesh Khanna,  Ajit Kumar Saxena,  M Shanmugavel,  Renu Moti Pandita
Affiliations

Affiliation

  • 1 Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. [email protected]
PMID: 15341949 DOI: 10.1016/j.bmcl.2004.07.036
Abstract

New pyrrolobenzodiazepine-anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many Cancer cell lines

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