2. Academic Validation
  3. Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells

Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells

  • Bioorg Med Chem Lett. 2004 Dec 6;14(23):5895-8. doi: 10.1016/j.bmcl.2004.09.022.
Eun-Jung Park 1,  Hye-Young Min,  Yong-Hyun Ahn,  Cheol-Man Bae,  Jae-Ho Pyee,  Sang Kook Lee
Affiliations

Affiliation

  • 1 College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Republic of Korea.
PMID: 15501064 DOI: 10.1016/j.bmcl.2004.09.022
Abstract

A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E(2) production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or Cancer chemopreventive agents.

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