2. Academic Validation
  3. Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors

Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors

  • J Med Chem. 2004 Dec 16;47(26):6603-8. doi: 10.1021/jm0401255.
Ariamala Gopalsamy 1,  Kitae Lim,  Gregory Ciszewski,  Kaapjoo Park,  John W Ellingboe,  Jonathan Bloom,  Shabana Insaf,  Janis Upeslacis,  Tarek S Mansour,  Girija Krishnamurthy,  Murthy Damarla,  Yelena Pyatski,  Douglas Ho,  Anita Y M Howe,  Mark Orlowski,  Boris Feld,  John O'Connell
Affiliations

Affiliation

  • 1 Chemical and Screening Sciences and Infectious Diseases, Wyeth Research, Pearl River, New York 10965, USA. [email protected]
PMID: 15588095 DOI: 10.1021/jm0401255
Abstract

A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.

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