2. Academic Validation
  3. Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1)

Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1)

  • J Nat Prod. 2005 Feb;68(2):207-11. doi: 10.1021/np0304518.
George R Pettit 1,  Noeleen Melody
Affiliations

Affiliation

  • 1 Cancer Research Institute, Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287-2404, USA.
PMID: 15730244 DOI: 10.1021/np0304518
Abstract

The synthesis of sodium narcistatin (8) was improved (88% overall yield) and the modified reaction sequence was utilized to synthesize three new 3,4-cyclic phosphate prodrugs, sodium 7-deoxynarcistatin (5), sodium 7-deoxy-trans-dihydronarcistatin (6), and sodium trans-dihydronarcistatin (7). The human Cancer cell line inhibitory isocarbostyril precursors were isolated from the bulbs of Hymenocallis littoralis obtained by horticultural production or reduction of narciclasine (1a --> 4) from the same source.

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