2. Academic Validation
  3. A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells

A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells

  • J Med Chem. 2005 Jul 28;48(15):5047-51. doi: 10.1021/jm058214k.
Lalji K Gediya 1,  Pankaj Chopra,  Puranik Purushottamachar,  Neha Maheshwari,  Vincent C O Njar
Affiliations

Affiliation

  • 1 Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201-1559, USA.
PMID: 16033284 DOI: 10.1021/jm058214k
Abstract

We have developed a procedure for the synthesis of N-hydroxy-N(1)-phenyloctanediamide (suberoylanilide hydroxamic acid (SAHA)), providing the product in 79.8% yield. SAHA is a potent inhibitor of histone deacetylase, induces differentiation and/or Apoptosis in certain transformed cells in culture, and suppressed the growth of human prostate Cancer LNCaP and PC-3 cell lines. The combination of SAHA with Other compounds inhibited cell proliferation of LNCaP cells in additive fashion and resulted in synergistic growth inhibition.

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