1. Academic Validation
  2. Free-radical-scavenging and xanthine oxidase inhibitory constituents from Stereospermum personatum

Free-radical-scavenging and xanthine oxidase inhibitory constituents from Stereospermum personatum

  • J Nat Prod. 2005 Nov;68(11):1615-21. doi: 10.1021/np058036y.
U Sampath Kumar 1 Ashok K Tiwari S Venkat Reddy P Aparna R Jagadeeshwar Rao A Zehra Ali J Madhusudana Rao
Affiliations

Affiliation

  • 1 Natural Products Laboratory, Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Abstract

Bioassay-guided fractionation of different extracts of both stem and stem bark of Stereospermum personatum led to the isolation of free-radical-scavenging and Xanthine Oxidase inhibitory molecules along with three new Anthraquinones, sterequinones F-H (1-3), a new naphthoquinone, sterequinone I (4), two new phenethyl esters, 2(4'-hydroxyphenyl)ethyl undecanoate (14) and 2(4'-hydroxyphenyl)ethyl nonacosanoate (15), and a new 3,4,5-trimethoxycinnamyl ether, 2-methoxy-4-[3'-(3'',4'',5''trimethoxyphenyl)allyloxymethyl]phenol (16), together with known compounds. The antioxidant and Xanthine Oxidase inhibitory potentials of the isolated compounds are reported.

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