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  3. Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

  • Phytochemistry. 2006 Dec;67(24):2651-8. doi: 10.1016/j.phytochem.2006.10.005.
Huizhen Liu 1,  Kent Gunnertoft Jensen,  Linh My Tran,  Ming Chen,  Lin Zhai,  Carl Erik Olsen,  Helmer Søhoel,  Samuel R Denmeade,  John T Isaacs,  S Brøgger Christensen
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
PMID: 17098264 DOI: 10.1016/j.phytochem.2006.10.005
Abstract

Four Phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the Phenylpropanoids has been developed. The Phenylpropanoids were found to be potent cytotoxins.

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