2. Academic Validation
  3. Synthesis and biological evaluation of novel analogues of dictyostatin

Synthesis and biological evaluation of novel analogues of dictyostatin

  • Bioorg Med Chem Lett. 2007 May 1;17(9):2443-7. doi: 10.1016/j.bmcl.2007.02.031.
Ian Paterson 1,  Nicola M Gardner,  Karine G Poullennec,  Amy E Wright
Affiliations

Affiliation

  • 1 University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK. [email protected]
PMID: 17336522 DOI: 10.1016/j.bmcl.2007.02.031
Abstract

Novel analogues of the microtubule-stabilising agent dictyostatin were designed using existing SAR information from the structurally related discodermolide, synthesised by a late-stage diversification strategy and evaluated in vitro for growth inhibition against a range of human Cancer cell lines, including those known to exhibit Taxol-resistance (AsPC-1, DLD-1, PANC-1, NCI/ADR).

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