2. Academic Validation
  3. 3-(2'-Bromopropionylamino)-benzamides as novel S-phase arrest agents

3-(2'-Bromopropionylamino)-benzamides as novel S-phase arrest agents

  • Bioorg Med Chem Lett. 2007 Dec 15;17(24):6847-52. doi: 10.1016/j.bmcl.2007.10.016.
Laixing Hu 1,  Zhuo-Rong Li,  Jian-Nong Li,  Jinrong Qu,  Jian-Dong Jiang,  David W Boykin
Affiliations

Affiliation

  • 1 Department of Chemistry, Georgia State University, Atlanta, GA 30303-3083, USA.
PMID: 17977727 DOI: 10.1016/j.bmcl.2007.10.016
Abstract

We report the synthesis, antiproliferative activity, and SAR of novel 3-(2'-bromopropionylamino)-benzamides. Many of the benzamide compounds showed potent cytotoxicities against Molt-3 leukemia cells. Several compounds exihibited cytotoxicities (under 6.5 microM) against five solid tumor cell lines. The mechanism of action of the most potent benzamide 10l does not involve targeting on tubulin but it causes cell cycle S-phase arrest. This active S-phase arrest agent merits further investigation.

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