Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population

Biochem Biophys Res Commun. 2008 Jan 18;365(3):466-71. doi: 10.1016/j.bbrc.2007.10.180.

Makoto Daimon ¹, Hidenori Sato, Toshihide Oizumi, Sayumi Toriyama, Takafumi Saito, Shigeru Karasawa, Yumi Jimbu, Kiriko Wada, Wataru Kameda, Shinji Susa, Hiroshi Yamaguchi, Mitsuru Emi, Masaaki Muramatsu, Isao Kubota, Sumio Kawata, Takeo Kato

Affiliations

Affiliation

1 Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.

PMID: 17991425 DOI: 10.1016/j.bbrc.2007.10.180

Abstract

The associations of five SNPs (SNPs1-5: A-5468G, A-3333G, C-1794T, C437T and T9148C) of the class II phosphoinositide 3-kinase gamma-subunit (PIK3C2G) gene with type 2 diabetes were examined using a population of the Takahata Study (n (M/W): 2930 (1328/1602); age: 63.3+/-10.2 years), a Japanese community-based study. Quantitative association study of the SNPs with HbA1c levels showed significant association for SNPs 2 and 4 (p=0.018 and 0.004, respectively). A case-control association study of SNP 4 with diabetes by multiple logistic regression analysis showed a significant association of the genotype TT of the SNP with an odds ratio of 2.21 (p=0.001) independently of age, gender and BMI. In the NGT subjects, serum fasting Insulin levels in the at-risk genotype group of SNP 4 were significantly lower than those in the Others (TT, TC, and CC, 4.9+/-2.6, 5.4+/-3.0, and 5.6+/-3.4muU/ml, respectively; p=0.029).

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