2. Academic Validation
  3. Calcium signaling

Calcium signaling

  • Cell. 2007 Dec 14;131(6):1047-58. doi: 10.1016/j.cell.2007.11.028.
David E Clapham 1
Affiliations

Affiliation

  • 1 Aldo R. Castañeda Professor of Cardiovascular Research, Professor of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Enders 1309, Children's Hospital Boston, Boston, MA 02115, USA. [email protected]
PMID: 18083096 DOI: 10.1016/j.cell.2007.11.028
Abstract

Calcium ions (CA(2+)) impact nearly every aspect of cellular life. This review examines the principles of CA(2+) signaling, from changes in protein conformations driven by CA(2+) to the mechanisms that control CA(2+) levels in the cytoplasm and organelles. Also discussed is the highly localized nature of CA(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, Apoptosis, and transcription.

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