2. Academic Validation
  3. Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity

Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity

  • Bioorg Med Chem. 2008 Apr 1;16(7):3780-90. doi: 10.1016/j.bmc.2008.01.052.
Kumiko Sako 1,  Hiroshi Aoyama,  Shinichi Sato,  Yuichi Hashimoto,  Masanori Baba
Affiliations

Affiliation

  • 1 Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
PMID: 18289862 DOI: 10.1016/j.bmc.2008.01.052
Abstract

Based on anti-viral screening of our heteroaromatics derived from thalidomide, the gamma-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-gamma-carboline), with the EC(50) of 0.26 microM.

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