2. Academic Validation
  3. Clavulanic acid: a review

Clavulanic acid: a review

  • Biotechnol Adv. 2008 Jul-Aug;26(4):335-51. doi: 10.1016/j.biotechadv.2008.03.002.
Parag S Saudagar 1,  Shrikant A Survase,  Rekha S Singhal
Affiliations

Affiliation

  • 1 Food Engineering and Technology Department, Institute of Chemical Technology, Nathalal Parikh Marg, Matunga, Mumbai 400 019, India.
PMID: 18450406 DOI: 10.1016/j.biotechadv.2008.03.002
Abstract

Natural Antibiotics are almost universal secondary metabolites, not essential for the growth of the producing organisms generally produced at low growth rates or after growth has ceased. Clavulanic acid (CA), a naturally occurring powerful inhibitor of Bacterial beta-lactamases is a major beta-lactam Antibiotic produced by organism Streptomyces clavuligerus and is active against a wide spectrum of Gram-positive and Gram-negative bacteria. The review discusses the biosynthetic pathway, fermentative production, downstream processing and applications of CA.

Figures
Products