2. Academic Validation
  3. Concise synthesis of PM-94128 and Y-05460M-A

Concise synthesis of PM-94128 and Y-05460M-A

  • J Org Chem. 2009 Oct 2;74(19):7566-9. doi: 10.1021/jo9014968.
Masaru Enomoto 1,  Shigefumi Kuwahara
Affiliations

Affiliation

  • 1 Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan.
PMID: 19722511 DOI: 10.1021/jo9014968
Abstract

The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-l-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved from N-Boc-l-valine by the same approach, which enabled its stereochemical determination.

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