2. Academic Validation
  3. Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb

Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb

  • Bioorg Med Chem Lett. 2010 May 1;20(9):2974-7. doi: 10.1016/j.bmcl.2010.02.107.
T Sreelatha 1,  A Hymavathi,  J Madhusudhana Murthy,  P U Rani,  J Madhusudana Rao,  K Suresh Babu
Affiliations

Affiliation

  • 1 Division of Organic Chemistry-I, Natural Product Laboratory, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
PMID: 20347303 DOI: 10.1016/j.bmcl.2010.02.107
Abstract

A bioassay-guided fractionation and chemical examination of chloroform extract of Plumbago capensis roots resulted in isolation and characterization of two new napthaquinone derivatives (4, 8) along with six known compounds (1-3, 5-7). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. All the compounds were tested for their mosquito larvicidal activity against fourth instar larvae of Aedes aegypti, and compared with that of rotenone. Among the tested compounds, isoshinanolone (3) and plumbagin (1) showed excellent toxicity with LC(50) values of 1.26 and 5.43 microg/mL. New compound (8) displayed moderate toxicity against the tested mosquito species.

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