Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation

Eur J Med Chem. 2010 Jul;45(7):2806-16. doi: 10.1016/j.ejmech.2010.03.002.

Davinder Kumar ¹, Vikramjeet Judge, Rakesh Narang, Sonia Sangwan, Erik De Clercq, Jan Balzarini, Balasubramanian Narasimhan

Affiliations

Affiliation

1 Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, India.

PMID: 20347509 DOI: 10.1016/j.ejmech.2010.03.002

Abstract

A series of benzylidene hydrazides (1-20) was synthesized and tested, in vitro, for Antibacterial, Antifungal and Antiviral activities. The microbial screening results indicated that compounds having chloro and nitro substituents were the most active ones. The Antiviral evaluation depicted that compounds 9 and 19 were active against Vesicular stomatitis virus (VSV) in HeLa cell cultures. QSAR investigations indicated that the multi-target QSAR model was effective in describing the antimicrobial (Antibacterial and Antifungal) activity over the one-target QSAR models. Further the mt-QSAR model indicated that the topological parameters, second order molecular connectivity index ((2)chi) and third order Kier's alpha shape index (kappaalpha(3)) are effective in describing the antimicrobial activity of synthesized hydrazides.

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