2. Academic Validation
  3. The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase

The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase

  • Bioorg Med Chem Lett. 2010 May 1;20(9):2968-73. doi: 10.1016/j.bmcl.2010.03.002.
Matthew G LaPorte 1,  Tandy L Draper,  Lori E Miller,  Charles W Blackledge,  Lara K Leister,  Eugene Amparo,  Alison R Hussey,  Dorothy C Young,  Srinivas K Chunduru,  Christopher A Benetatos,  Gerry Rhodes,  Ariamala Gopalsamy,  Torsten Herbertz,  Christopher J Burns,  Stephen M Condon
Affiliations

Affiliation

  • 1 University of Pittsburgh, Center for Chemical Methodologies and Library Development, Pittsburgh, PA 15260, USA. [email protected]
PMID: 20347591 DOI: 10.1016/j.bmcl.2010.03.002
Abstract

We describe the structure-activity relationship of the C1-group of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compound 12.

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