2. Academic Validation
  3. Synthesis and antifungal activity of carabrone derivatives

Synthesis and antifungal activity of carabrone derivatives

  • Molecules. 2010 Sep 16;15(9):6485-92. doi: 10.3390/molecules15096485.
Jun-Tao Feng 1,  Zhi-Qing Ma,  Jiang-Hua Li,  Jun He,  Hui Xu,  Xing Zhang
Affiliations

Affiliation

  • 1 Research and Development Center of Biorational Pesticide, College of Plant Protection, Northwest A&F University, Yangling, China. [email protected]
PMID: 20877238 DOI: 10.3390/molecules15096485
Abstract

Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent Antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the Antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the Antifungal activity.

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