2. Academic Validation
  3. Lifting the nebula: novel insights into skeletal muscle contractility

Lifting the nebula: novel insights into skeletal muscle contractility

  • Physiology (Bethesda). 2010 Oct;25(5):304-10. doi: 10.1152/physiol.00016.2010.
Coen A C Ottenheijm 1,  Henk Granzier
Affiliations

Affiliation

  • 1 Department of Physiology, University of Arizona, Tucson, AZ, USA.
PMID: 20940435 DOI: 10.1152/physiol.00016.2010
Abstract

Nebulin is a giant protein and a constituent of the skeletal muscle sarcomere. The name of this protein refers to its unknown (i.e., nebulous) function. However, recent rapid advances reveal that nebulin plays important roles in the regulation of muscle contraction. When these functions of nebulin are compromised, muscle weakness ensues, as is the case in patients with nemaline myopathy.

Figures