2. Academic Validation
  3. Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708

Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708

  • J Nat Prod. 2012 Oct 26;75(10):1729-34. doi: 10.1021/np300329m.
Ling Ding 1,  Basile Le Sage Tchize Ndejouong,  Armin Maier,  Heinz-Herbert Fiebig,  Christian Hertweck
Affiliations

Affiliation

  • 1 Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Beutenbergstraße 11a, 07745 Jena, Germany.
PMID: 23013356 DOI: 10.1021/np300329m
Abstract

Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure-activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.

Figures