2. Academic Validation
  3. Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas

Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas

  • Cancer Lett. 2013 Jun 1;333(1):76-88. doi: 10.1016/j.canlet.2013.01.020.
Nadia Lounnas 1,  Célia Rosilio,  Marielle Nebout,  Didier Mary,  Emmanuel Griessinger,  Zouhour Neffati,  Johanna Chiche,  Hergen Spits,  Thijs J Hagenbeek,  Vahid Asnafi,  Sally-Ann Poulsen,  Claudiu T Supuran,  Jean-François Peyron,  Véronique Imbert
Affiliations

Affiliation

  • 1 INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Team 4, Inflammation, Cancer, Cellules Souches Cancéreuses, Nice, France.
PMID: 23348702 DOI: 10.1016/j.canlet.2013.01.020
Abstract

The membrane-bound Carbonic Anhydrase isoforms CAIX and CAXII, underpin a pH-regulating system that enables hypoxic tumor cell survival. Here, we observed for the first time an upregulation of CAXII in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LL) cells. First we showed that CAXII is overexpressed in thymocytes from tPTEN-/- mice suffering of T lymphoma and that its pharmacological inhibition decreased cell proliferation and induced Apoptosis. The same results were observed with the SupT1 human T cell lymphoma line. In addition we observed an upregulation of CAXII in human T-ALL samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL.

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