2. Academic Validation
  3. Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins

Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins

  • Adv Mater. 2013 Nov 6;25(41):5869-74. doi: 10.1002/adma.201301338.
Sabri Rahmouni 1,  Aaron Lindner,  Florian Rechenmacher,  Stefanie Neubauer,  Tariq Rashad Ali Sobahi,  Horst Kessler,  Elisabetta Ada Cavalcanti-Adam,  Joachim Pius Spatz
Affiliations

Affiliation

  • 1 Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, 70569, Stuttgart, Germany; Department of Biophysical Chemistry, University of Heidelberg, Im Neuenheimer Feld 253, 69120, Heidelberg, Germany.
PMID: 23913640 DOI: 10.1002/adma.201301338
Abstract

Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two Integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5β1- and αvβ3-integrins. Cells adherent via α5β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3-integrins.

Keywords

cell adhesion; integrin; micropillar; peptidomimetics; traction force.

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