2. Academic Validation
  3. A novel and other bioactive secondary metabolites from a marine fungus Penicillium oxalicum 0312F1

A novel and other bioactive secondary metabolites from a marine fungus Penicillium oxalicum 0312F1

  • Nat Prod Res. 2013;27(24):2286-91. doi: 10.1080/14786419.2013.827190.
Shuo Shen 1,  Wei Li,  Jian Wang
Affiliations

Affiliation

  • 1 a Institute of Biotechnology of Qinghai Academy of Agriculture and Forestry , Xining , 810016 , P.R. China.
PMID: 23962399 DOI: 10.1080/14786419.2013.827190
Abstract

A new compound 2-(4-hydroxybenzoyl) quinazolin-4(3H)-one (1) and four known compounds were isolated from a marine fungus Penicillium oxalicum 0312F1. The structure of the new compound 1 was elucidated based on the spectroscopic analysis. Bioactivity assays showed that 2-(4-hydroxybenzyl) quinazolin-4(3H)-one (2) and methyl 4-hydroxyphenylacetate (5) had potent inhibitory activity against tobacco mosaic virus (TMV), and the new compound 1 had moderate inhibitory activity against TMV and human gastric Cancer cell SGC-7901.

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