2. Academic Validation
  3. Diterpenoids and sesquiterpenoids from the roots of Illicium majus

Diterpenoids and sesquiterpenoids from the roots of Illicium majus

  • J Nat Prod. 2013 Oct 25;76(10):1976-83. doi: 10.1021/np400638r.
Ya-Dan Wang 1,  Gui-Jie Zhang,  Jing Qu,  Yu-Huan Li,  Jian-Dong Jiang,  Yun-Bao Liu,  Shuang-Gang Ma,  Yong Li,  Hai-Ning Lv,  Shi-Shan Yu
Affiliations

Affiliation

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
PMID: 24070022 DOI: 10.1021/np400638r
Abstract

Five new Diterpenoids (1-5), five new sesquiterpenoids (6-10), and three known compounds (11-13) were isolated from the roots of Illicium majus. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was assigned by X-ray crystallography, whereas those of the 1,2-diol moieties in 3 and 4 were determined using Snatzke's method. The abietane acids 1, 2, 11, 12, and 13 displayed Antiviral activity against the Coxsackie B3 virus, with IC50 values of 3.3-51.7 μM/mL.

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