2. Academic Validation
  3. Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity

Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity

  • Medchemcomm. 2011 Jul 1;2(7):10.1039/C1MD00094B. doi: 10.1039/C1MD00094B.
Sarah C Zimmermann 1,  Joshua M Sadler,  Graciela Andrei,  Robert Snoeck,  Jan Balzarini,  Katherine L Seley-Radtke
Affiliations

Affiliation

  • 1 Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA.
PMID: 24312722 DOI: 10.1039/C1MD00094B
Abstract

A series of 5'-nor carbocyclic "reverse" flexible nucleosides or "fleximers" have been designed wherein the nucleobase scaffold resembles a "split" purine as well as a substituted pyrimidine. This modification was employed to explore recognition by both purine and pyrimidine metabolizing Enzymes. The synthesis of the carbocyclic fleximers and the results of their preliminary biological screening are described herein.

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