2. Academic Validation
  3. Sorbicatechols A and B, antiviral sorbicillinoids from the marine-derived fungus Penicillium chrysogenum PJX-17

Sorbicatechols A and B, antiviral sorbicillinoids from the marine-derived fungus Penicillium chrysogenum PJX-17

  • J Nat Prod. 2014 Feb 28;77(2):424-8. doi: 10.1021/np400977e.
Jixing Peng 1,  Xiaomin Zhang,  Lin Du,  Wei Wang,  Tianjiao Zhu,  Qianqun Gu,  Dehai Li
Affiliations

Affiliation

  • 1 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
PMID: 24495078 DOI: 10.1021/np400977e
Abstract

Two novel sorbicillinoids combining a bicyclo[2.2.2]octane with a 2-methoxyphenol moiety, named sorbicatechols A (1) and B (2), were isolated from the culture of the marine sediment-derived fungus Penicillium chrysogenum PJX-17, together with the known protocatechuic acid methyl ester and caffeic acid methyl ester (3). Their structures, including absolute configurations, were assigned by analysis of NMR, MS data, and TDDFT ECD calculations. Compounds 1 and 2 exhibited activities against Influenza Virus A (H1N1), with IC50 values of 85 and 113 μ M, respectively.

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