2. Academic Validation
  3. Chemical constituents from the leaves of Juglans mandshurica

Chemical constituents from the leaves of Juglans mandshurica

  • Arch Pharm Res. 2015 Apr;38(4):480-4. doi: 10.1007/s12272-014-0398-1.
Da Lei Yao 1,  Chang Hao Zhang,  Jie Luo,  Mei Jin,  Ming Shan Zheng,  Jiong Mo Cui,  Jong Keun Son,  Gao Li
Affiliations

Affiliation

  • 1 Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People's Republic of China.
PMID: 24748532 DOI: 10.1007/s12272-014-0398-1
Abstract

Two new (1 and 3) and two known diarylheptanoids (2 and 4), along with two tetralones (5 and 6), one naphthoquinone (7), four Phenylpropanoids (8-11), and one phenol (12) were isolated from the leaves of Juglans mandshurica. Their structures were elucidated on the basis of spectral and chemical data. Compounds 2 and 10 are firstly isolated from this plant and 8 and 12 were isolated from the Juglans genus for the first time. Among these compounds, only 7 exhibited moderate cytotoxicities against cultured MGC-803, A549, K562, and HeLa tumor cell lines with IC50 values of 25.90, 28.60, 39.06, 44.90 μM, respectively.

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