2. Academic Validation
  3. Eleganketal A, a highly oxygenated dibenzospiroketal from the marine-derived fungus Spicaria elegans KLA03

Eleganketal A, a highly oxygenated dibenzospiroketal from the marine-derived fungus Spicaria elegans KLA03

  • J Nat Prod. 2014 Jul 25;77(7):1718-23. doi: 10.1021/np500458a.
Yepeng Luan 1,  Hongjuan Wei,  Zhenpei Zhang,  Qian Che,  Yankai Liu,  Tianjiao Zhu,  Attila Mándi,  Tibor Kurtán,  Qianqun Gu,  Dehai Li
Affiliations

Affiliation

  • 1 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
PMID: 24967847 DOI: 10.1021/np500458a
Abstract

Eleganketal A (1), a naturally occurring aromatic polyketide possessing a rare highly oxygenated spiro[isobenzofuran-1,3'-isochroman] ring system, was isolated from the fungus Spicaria elegans KLA03 by culturing it in a modified mannitol-based medium. The structure of 1 including the absolute configuration was determined by combining spectroscopic analysis, synthesis of the racemic permethylated analogue, chiral-phase HPLC separation, and TDDFT-ECD analysis.

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