2. Academic Validation
  3. PM00104 (Zalypsis®): a marine derived alkylating agent

PM00104 (Zalypsis®): a marine derived alkylating agent

  • Molecules. 2014 Aug 15;19(8):12328-35. doi: 10.3390/molecules190812328.
Bradley J Petek 1,  Robin L Jones 2
Affiliations

Affiliations

  • 1 University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA. [email protected].
  • 2 Fred Hutchinson Cancer Research Center, University of Washington, 825 Eastlake Avenue East, G-3630, Seattle, WA 98109-1023, USA. [email protected].
PMID: 25153860 DOI: 10.3390/molecules190812328
Abstract

PM00104 (Zalypsis®) is a synthethic tetrahydroisoquinolone alkaloid, which is structurally similar to many marine organisms. The compound has been proposed as a potential chemotherapeutic agent in the treatment of solid human tumors and hematological malignancies. PM00104 is a DNA binding agent, causing inhibition of the cell cycle and transcription, which can lead to double stranded DNA breaks. After rigorous pre-clinical testing, the drug has been evaluated in a number of phase II clinical trials. This manuscript provides a review of current trials and appraises the efficacy of PM00104 as a future Cancer treatment.

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