2. Academic Validation
  3. Dihydrochalcones and homoisoflavanes from the red resin of Dracaena cochinchinensis (Chinese dragon's blood)

Dihydrochalcones and homoisoflavanes from the red resin of Dracaena cochinchinensis (Chinese dragon's blood)

  • Fitoterapia. 2014 Dec;99:64-71. doi: 10.1016/j.fitote.2014.09.006.
Xiao-Qin Su 1,  Yue-Lin Song 2,  Jing Zhang 1,  Hui-Xia Huo 1,  Zheng Huang 1,  Jiao Zheng 2,  Qian Zhang 2,  Yun-Fang Zhao 2,  Wei Xiao 3,  Jun Li 4,  Peng-Fei Tu 5
Affiliations

Affiliations

  • 1 Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, People's Republic of China.
  • 2 Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
  • 3 National Key Laboratory of Pharmaceutical New Technology for Chinese Medicine, Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222001, People's Republic of China.
  • 4 Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China. Electronic address: [email protected].
  • 5 Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China. Electronic address: [email protected].
PMID: 25218969 DOI: 10.1016/j.fitote.2014.09.006
Abstract

Two new Dihydrochalcones, 4-hydroxy-2,4'-dimethoxydihydrochalcone (1) and 3,4'-dihydroxy-2,4,6-trimethoxydihydrochalcone (2), and a new homoisoflavane, 7,3'-dihydroxy-8,4'-dimethoxyhomoisoflavane (3), along with 12 known compounds (4-15), were isolated from the red resin of Dracaena cochinchinensis (Chinese dragon's blood). Their structures were assigned by a variety of spectroscopic techniques. Diversity of cleavage pathways were proposed for Dihydrochalcones and homoisoflavanes based on the mass spectroscopic behaviors of those identified compounds using hybrid ion trap-time of flight mass spectrometry. All the compounds were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages, and compound 9 exhibited mild inhibition of NO production in this assay with IC₅₀ value of 50.3 μM.

Keywords

2,4,4′-trihydroxydihydrochalcone (PubChem CID: 10801179); Chinese dragon's blood; Dihydrochalcone; Dracaena cochinchinensis; Homoisoflavane; Loureirin A (PubChem CID: 5319081); Loureirin B (PubChem CID: 189670); Loureirin C (PubChem CID: 14157896); Loureirin D (PubChem CID: 13939318); Mass fragmentation pathway.

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