2. Academic Validation
  3. Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook

Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook

  • Bioorg Med Chem Lett. 2014 Nov 15;24(22):5268-73. doi: 10.1016/j.bmcl.2014.09.052.
Feng-Qing Xu 1,  Fang-Cheng Xu 2,  Bo Hou 3,  Wei-Wei Fan 3,  Cheng-Ting Zi 3,  Yan Li 3,  Fa-Wu Dong 3,  Yu-Qing Liu 3,  Jun Sheng 4,  Zhi-Li Zuo 5,  Jiang-Miao Hu 6
Affiliations

Affiliations

  • 1 Anhui University of Chinese Medicine, Hefei 230031, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • 2 The Department of Neurology of the First Affiliated Hospital of Medical University of Anhui, China.
  • 3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • 4 Yunnan Agricultural University, Kunming 650201, China. Electronic address: [email protected].
  • 5 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: [email protected].
  • 6 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: [email protected].
PMID: 25316316 DOI: 10.1016/j.bmcl.2014.09.052
Abstract

The bioassay-guided chemical investigation of the stems of Dendrobium fimbriatum Hook led to the isolation of seven first reported bibenzyl dimers with a linkage of a methylene moiety, fimbriadimerbibenzyls A-G (1-7), together with a new dihydrophenanthrene derivative (S)-2,4,5,9-tetrahydroxy-9,10-dihydrophenanthrene (8) and thirteen known compounds (9-21). The structure of the new compound was established by spectroscopic analysis. Biological evaluation of bibenzyl derivatives against five human cell lines indicated that seven of those compounds exhibited broad-spectrum and cytotoxic activities with IC50 values ranging from 2.2 to 21.2 μM. Those rare bibenzyl dimers exhibited cytotoxic activities in vitro and the cytotoxicity decreased as the number of oxygen-containing groups in the structure decreases.

Keywords

Bibenzyl dimer; Cytotoxicity; Dendrobium fimbriatum Hook; Fimbriadimerbibenzyl.

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