2. Academic Validation
  3. BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development

BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development

  • Gene. 2015 Jan 10;554(2):196-204. doi: 10.1016/j.gene.2014.10.047.
Yang Wang 1,  Wen-Hua Li 2,  Zhi Li 1,  Wei Liu 2,  Li Zhou 1,  Jian-Fang Gui 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
  • 2 State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China; University of the Chinese Academy of Sciences, Wuhan, China.
  • 3 State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China. Electronic address: [email protected].
PMID: 25445289 DOI: 10.1016/j.gene.2014.10.047
Abstract

Apolipoproteins, the major components of lipoproteins, play physiological roles in lipoprotein metabolism. Contrary to the well-documented effects on plasma lipid, little is known about the function and regulation of Apolipoproteins during embryonic development. Here we have shown that Apolipoprotein C1 (apoc1) gene is highly expressed in the yolk syncytial layer, a structure implicated in embryonic and larval nutrition. The apoc1 transcripts are also observed in the deep cell layer at the ventral and lateral region during gastrulation, and in the tail paraxial mesoderm during somitogenesis. By whole-mount in situ hybridization and quantified RT-RCR, we further demonstrate that apoc1 expression is induced by bone morphogenetic proteins (BMPs) signaling, while retinoic acid (RA) signaling suppresses the expression of BMP ligands and inhibits the BMP effect in this process.

Keywords

Apolipoprotein C1; Bone morphogenetic proteins; Embryonic development; Retinoic acid.

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