2. Academic Validation
  3. Cytotoxic indole alkaloids from Tabernaemontana officinalis

Cytotoxic indole alkaloids from Tabernaemontana officinalis

  • Phytochemistry. 2015 Dec;120:46-52. doi: 10.1016/j.phytochem.2014.12.025.
Bing-Jie Zhang 1,  Xi-Feng Teng 2,  Mei-Fen Bao 3,  Xiu-Hong Zhong 1,  Ling Ni 1,  Xiang-Hai Cai 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
  • 2 School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
  • 3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
  • 4 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: [email protected].
PMID: 25687604 DOI: 10.1016/j.phytochem.2014.12.025
Abstract

Continued interest in cytotoxic Alkaloids resulted in the isolation of 37 Alkaloids including 29 known monoterpenoid Indole Alkaloids from the aerial parts of Tabernaemontana officinalis. Of the remaining 8 Alkaloids, six were bisindole Alkaloids named taberdivarines A-F (1-6) and the two were monomers named taberdivarines G and H (7-8). Alkaloids 1 and 2 are voaphylline-vobasinyl type bisindole Alkaloids, a structural type previously unknown, while 3-6 exhibited cytotoxicity against three human Cancer cell lines HeLa, MCF-7, and SW480 with IC50 values ranging from 1.42 to 11.35 μM.

Keywords

Apocynaceae; Bisindole alkaloid; Cytotoxicity; Monoterpenoid indole alkaloid; Tabernaemontana officinalis.

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