2. Academic Validation
  3. Phenolic Compounds from the Roots of Rhodiola crenulata and Their Antioxidant and Inducing IFN-γ Production Activities

Phenolic Compounds from the Roots of Rhodiola crenulata and Their Antioxidant and Inducing IFN-γ Production Activities

  • Molecules. 2015 Jul 28;20(8):13725-39. doi: 10.3390/molecules200813725.
Jiang-Tao Zhou 1 2,  Chen-Yang Li 3,  Chun-Hua Wang 4 5,  Yue-Fei Wang 6,  Xiao-Dong Wang 7,  Hong-Tao Wang 8,  Yan Zhu 9 10,  Miao-Miao Jiang 11 12,  Xiu-Mei Gao 13
Affiliations

Affiliations

  • 1 Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. [email protected].
  • 2 Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China. [email protected].
  • 3 Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China. [email protected].
  • 4 Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. [email protected].
  • 5 Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China. [email protected].
  • 6 Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. [email protected].
  • 7 Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China. [email protected].
  • 8 Shijiazhuang Yiling Pharmaceutical Co., Ltd, Shijiazhuang 050035, China. [email protected].
  • 9 Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. [email protected].
  • 10 Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China. [email protected].
  • 11 Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. [email protected].
  • 12 Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China. [email protected].
  • 13 Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. [email protected].
PMID: 26225952 DOI: 10.3390/molecules200813725
Abstract

In the present study, two new phenolic compounds 1 and 11, a pair of lignan isomers 12 and 13 with their absolute configurations established for the first time, were isolated from the ethanol extract of the roots of Rhodiola crenulata, together with 13 known phenolic compounds, and their structures were elucidated via NMR, HRESIMS, UV, IR and CD analyses. All the isolated compounds were evaluated for their in vitro antioxidant activities using the 2,2-diphenyl-1-picryhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays. Ten of them exhibited significant antioxidant activities compared to ascorbic acid. Furthermore, the inducibilities of the isolated compounds to IFN-γ production were also assessed. Compounds 1, 8, 9, 12, 13, 14 and 15 could moderately stimulate IFN-γ expression.

Keywords

IFN-γ production; Rhodiola crenulata; antioxidant activity; immunomodulatory effect; phenol.

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