Nocarbenzoxazoles A-G, Benzoxazoles Produced by Halophilic Nocardiopsis lucentensis DSM 44048

J Nat Prod. 2015 Aug 28;78(8):2123-7. doi: 10.1021/acs.jnatprod.5b00031.

Mingwei Sun ¹, Xiaomei Zhang ², Huilin Hao ¹, Wenjun Li ², Chunhua Lu ¹

Affiliations

1 Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan, Shandong 250012, People's Republic of China.
2 Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education and Laboratory for Conservation and Utilization of Bio-Resources, Yunnan Institute of Microbiology, Yunnan University , Kunming, Yunnan 650091, People's Republic of China.

PMID: 26270803 DOI: 10.1021/acs.jnatprod.5b00031

Abstract

Seven new benzoxazole derivatives, nocarbenzoxazoles A-G (1-7), were isolated from the halophilic strain Nocardiopsis lucentensis DSM 44048. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data, HRESIMS, and X-ray single-crystal diffraction. The isolated compounds were assayed for their cytotoxicity against a panel of human tumor cell lines (HepG2, MDA-MB-231, MDA-MB-435, HeLa, and PC3). Compounds 1-6 were found to have modest or no activity. Compound 7 showed selective activity against HepG2 and HeLa with IC₅₀ values of 3 and 1 μM, respectively.

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