2. Academic Validation
  3. Present Yourself! By MHC Class I and MHC Class II Molecules

Present Yourself! By MHC Class I and MHC Class II Molecules

  • Trends Immunol. 2016 Nov;37(11):724-737. doi: 10.1016/j.it.2016.08.010.
Kenneth L Rock 1,  Eric Reits 2,  Jacques Neefjes 3
Affiliations

Affiliations

  • 1 Department of Pathology, UMass Medical School, Worcester, MA, USA.
  • 2 Department of Cell Biology and Histology, Amsterdam Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
  • 3 Department of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Chemical Immunology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: [email protected].
PMID: 27614798 DOI: 10.1016/j.it.2016.08.010
Abstract

Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of the proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system. We now understand that the MHC system shapes both the repertoire of presented peptides and the subsequent T cell response, with important implications ranging from transplant rejection to tumor immunotherapies. Here we present an illustrated review of the ins and outs of MHC class I and MHC class II antigen presentation.

Keywords

MHC class I; MHC class II; antigen presentation; autoimmune diseases; transplantation; tumor immunology.

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