2. Academic Validation
  3. Bioactive compounds from the root of Myrsine africana

Bioactive compounds from the root of Myrsine africana

  • J Nat Prod. 1989 May-Jun;52(3):660-2. doi: 10.1021/np50063a035.
X H Li 1,  J L McLaughlin
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
PMID: 2778455 DOI: 10.1021/np50063a035
Abstract

Bioactivity-directed fractionation of the EtOH extract of the roots of Myrsine africana, using lethality to brine shrimp, led to the isolation and identification of emodin and 2-hydroxychrysophanol as cytotoxic components, the latter being a new natural product. Nepodin and 5-methoxy-7-hydroxyphthalide were also isolated but were not significantly cytotoxic.

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