2. Academic Validation
  3. Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils

Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils

  • Fitoterapia. 2017 Mar:117:16-21. doi: 10.1016/j.fitote.2016.12.008.
Lin-Yang Cheng 1,  Hsiang-Ruei Liao 2,  Li-Chai Chen 3,  Shih-Wei Wang 4,  Yueh-Hsiung Kuo 5,  Mei-Ing Chung 1,  Jih-Jung Chen 6
Affiliations

Affiliations

  • 1 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
  • 2 Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
  • 3 Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan; Department of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 81342, Taiwan.
  • 4 Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan.
  • 5 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan; Department of Biotechnology, Asia University, Taichung 41354, Taiwan.
  • 6 Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan. Electronic address: [email protected].
PMID: 28012920 DOI: 10.1016/j.fitote.2016.12.008
Abstract

Two new naphthofuranone derivatives, 11-hydroxy-2-O-methylhibiscolactone A (1) and O-methylhibiscone D (2), have been isolated from the stems of Pachira aquatica, together with 18 known compounds (3-20). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 11-hydroxy-2-O-methylhibiscolactone A (1), isohemigossylic acid lactone-7-methyl ether (4), gmelofuran (6), and 5-hydroxyauranetin (8) exhibited inhibition (IC50≤28.84μM) of superoxide anion generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).

Keywords

Anti-inflammatory activity; Bombacaceae; Naphthofuranone; Pachira aquatica; Structure elucidation.

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