2. Academic Validation
  3. C21 steroidal glycosides and oligosaccharides from the root bark of Periploca sepium

C21 steroidal glycosides and oligosaccharides from the root bark of Periploca sepium

  • Fitoterapia. 2017 Apr:118:6-12. doi: 10.1016/j.fitote.2017.02.005.
Xin-Yue Gu 1,  Zhou-Wei Wu 1,  Lun Wang 2,  Fu Li 2,  Bin Chen 2,  Kai Yu 3,  Ming-Kui Wang 4
Affiliations

Affiliations

  • 1 Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • 2 Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
  • 3 School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610013, China.
  • 4 Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address: [email protected].
PMID: 28214554 DOI: 10.1016/j.fitote.2017.02.005
Abstract

Four new C21 steroidal glycosides (1-4), named perisepiumosides FI (1-4) together with six known steroidal glycosides (5-10) and four oligosaccharides (11-14), were isolated from the root bark of Periploca sepium. Their structures were characterized on the basis of 1D and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. The evaluation of inhibition activity against human A-549 and HepG2 cell lines indicated that compounds 2, 8, 10 and 13 showed different levels of cytotoxic activities with IC50 values ranging from 0.61 to 7.86μM.

Keywords

C(21) steroidal glycosides; Cytotoxic activities; Oligosaccharides; Periploca sepium.

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