2. Academic Validation
  3. 1,3,5-Triazines: A promising scaffold for anticancer drugs development

1,3,5-Triazines: A promising scaffold for anticancer drugs development

  • Eur J Med Chem. 2017 Dec 15:142:523-549. doi: 10.1016/j.ejmech.2017.09.035.
Stella Cascioferro 1,  Barbara Parrino 1,  Virginia Spanò 1,  Anna Carbone 1,  Alessandra Montalbano 1,  Paola Barraja 1,  Patrizia Diana 1,  Girolamo Cirrincione 2
Affiliations

Affiliations

  • 1 Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.
  • 2 Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy. Electronic address: [email protected].
PMID: 29046238 DOI: 10.1016/j.ejmech.2017.09.035
Abstract

This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the structure-activity relationship and, whenever reported, the possible mechanism of action of 1,3,5-triazine derivatives as well as of their hetero-fused compounds. Many 1,3,5-triazine derivatives, both uncondensed and hetero-fused, have shown remarkable antitumor activities and some of them reached clinical development.

Keywords

1,3,5-Triazines; Antitumor activity; Disubstituted 1,3,5-triazines; Heterofused 1,3,5-triazines; Nitrogen heterocycles; Trisubstituted 1,3,5-triazines.

Figures