2. Academic Validation
  3. New iridoid glycosides from the fruits of Forsythia suspensa and their hepatoprotective activities

New iridoid glycosides from the fruits of Forsythia suspensa and their hepatoprotective activities

  • Bioorg Chem. 2017 Dec:75:303-309. doi: 10.1016/j.bioorg.2017.10.006.
Si-Yuan Shao 1,  Ya-Nan Yang 1,  Zi-Ming Feng 1,  Jian-Shuang Jiang 1,  Pei-Cheng Zhang 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • 2 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: [email protected].
PMID: 29078206 DOI: 10.1016/j.bioorg.2017.10.006
Abstract

A novel iridoid glycoside trimer named forsydoitriside A (1) and five new iridoid glycosides (2-6) were isolated from the fruits of Forsythia suspensa together with two known compounds (7, 8). These new structures were elucidated by comprehensive spectroscopic data and the comparison of experimental and calculated electronic circular dichroism spectra. Compounds 1-8 were all assayed on acetaminophen-induced HepG2 cell damage. The results exhibited that compounds 2, 3, 5 and 6 possessed strong hepatoprotective activities against the damage in HepG2 cell.

Keywords

Forsythia suspensa; Hepatoprotective activity; Iridoid glycosides; Trimer.

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