2. Academic Validation
  3. Isosteric ribavirin analogues: Synthesis and antiviral activities

Isosteric ribavirin analogues: Synthesis and antiviral activities

  • Bioorg Med Chem Lett. 2018 Jan 1;28(1):11-14. doi: 10.1016/j.bmcl.2017.11.029.
Nikolay I Zhurilo 1,  Mikhail V Chudinov 2,  Andrey V Matveev 1,  Olga S Smirnova 3,  Irina D Konstantinova 3,  Anatoly I Miroshnikov 3,  Alexander N Prutkov 4,  Lyubov E Grebenkina 4,  Natalya V Pulkova 4,  Vitaly I Shvets 1
Affiliations

Affiliations

  • 1 Lomonosov Institute of Fine Chemical Tehnologies, Moscow Technological University, Vernadskogo Pr. 78, 119454 Moscow, Russia.
  • 2 Lomonosov Institute of Fine Chemical Tehnologies, Moscow Technological University, Vernadskogo Pr. 78, 119454 Moscow, Russia. Electronic address: [email protected].
  • 3 Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St. 16/10, 117997 GSP, Moscow B-437, Russia.
  • 4 Moscow Politechnical University, Bolshaya Semenovskaya Str., 38, 107023 Moscow, Russia.
PMID: 29173944 DOI: 10.1016/j.bmcl.2017.11.029
Abstract

The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant Antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible Antiviral activity mechanism related with bioisosterism.

Keywords

Antivirals; Isosterism; Nucleoside analogues; Ribavirin.

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