2. Academic Validation
  3. The Immunogenetics of Psoriasis and Implications for Drug Repositioning

The Immunogenetics of Psoriasis and Implications for Drug Repositioning

  • Int J Mol Sci. 2017 Dec 8;18(12):2650. doi: 10.3390/ijms18122650.
Xuan Xu 1,  Hong-Yu Zhang 2
Affiliations

Affiliations

  • 1 Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China. [email protected].
  • 2 Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China. [email protected].
PMID: 29292715 DOI: 10.3390/ijms18122650
Abstract

Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease's development, are greatly limited because its etiology and pathogenesis have not yet been fully elucidated. A large number of studies have demonstrated that immunogenetic elements are the most important factors responsible for psoriasis susceptibility. This paper delineates the immunogenetic mechanisms of psoriasis and provides useful information with regards to performing drug repositioning for the treatment of psoriasis.

Keywords

drug repositioning; genetics; immunogenetics; psoriasis; susceptible genes.

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