2. Academic Validation
  3. The Role of Mst1 in Lymphocyte Homeostasis and Function

The Role of Mst1 in Lymphocyte Homeostasis and Function

  • Front Immunol. 2018 Feb 5:9:149. doi: 10.3389/fimmu.2018.00149.
Jiali Cheng 1,  Yukai Jing 1,  Danqing Kang 1,  Lu Yang 1,  Jingwen Li 1,  Ze Yu 1,  Zican Peng 1,  Xingbo Li 1,  Yin Wei 2,  Quan Gong 3 4,  Richard J Miron 5,  Yufeng Zhang 5,  Chaohong Liu 1
Affiliations

Affiliations

  • 1 Department of Microbiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 2 Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 3 Department of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
  • 4 Clinical Molecular Immunology Center, School of Medicine, Yangtze University, Jingzhou, China.
  • 5 State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
PMID: 29459865 DOI: 10.3389/fimmu.2018.00149
Abstract

The Hippo pathway is an evolutionarily conserved pathway crucial for regulating tissue size and for limiting Cancer development. However, recent work has also uncovered key roles for the mammalian Hippo kinases, Mst1/2, in driving appropriate immune responses by directing T cell migration, morphology, survival, differentiation, and activation. In this review, we discuss the classical signaling pathways orchestrated by the Hippo signaling pathway, and describe how Mst1/2 direct T cell function by mechanisms not seeming to involve the classical Hippo pathway. We also discuss why Mst1/2 might have different functions within organ systems and the immune system. Overall, understanding how Mst1/2 transmit signals to discrete biological processes in different cell types might allow for the development of better drug therapies for the treatments of cancers and immune-related diseases.

Keywords

apoptosis; hippo; lymphocyte; migration; proliferation.

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