2. Academic Validation
  3. Regulation of cancer immune escape: The roles of miRNAs in immune checkpoint proteins

Regulation of cancer immune escape: The roles of miRNAs in immune checkpoint proteins

  • Cancer Lett. 2018 Sep 1;431:73-84. doi: 10.1016/j.canlet.2018.05.015.
Qin Yang 1,  Wenjie Cao 2,  Zi Wang 3,  Bin Zhang 4,  Jing Liu 5
Affiliations

Affiliations

  • 1 Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, China; School of Medical Laboratory, Shao Yang University, Hunan Province, 422000, China.
  • 2 Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, China; Department of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, 410013, China.
  • 3 Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, China; Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • 4 Department of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, 410013, China. Electronic address: [email protected].
  • 5 Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, China. Electronic address: [email protected].
PMID: 29800685 DOI: 10.1016/j.canlet.2018.05.015
Abstract

Immune Checkpoint Proteins (ICPs) are regulators of immune system. The ICP dysregulation silences the host immune response to cancer-specific antigens, contributing to the occurrence and progress of various cancers. MiRNAs are regulatory molecules and function in mRNA silencing and post-transcriptional regulation of gene expression. MiRNAs that modulate the immunity via ICPs have received increasing attention. Many studies have shown that the expressions of ICPs are directly or indirectly repressed by miRNAs in multiple types of cancers. MiRNAs are also subject to regulation by ICPs. In this review, recent studies of the relationship between miRNAs and ICPs (including the PD-1, PD-L1, CTLA-4, ICOS, B7-1, B7-2, B7-H2, B7-H3, CD27, CD70, CD40, and CD40L) in Cancer immune escape are comprehensively discussed, which provide critical detailed mechanistic insights into the functions of the miRNA-ICP axes and their effects on immune escape, and will be beneficial for the potential applications of immune checkpoint therapy and miRNA-based guidance for personalized medicine as well as for predicting the prognosis.

Keywords

Cancer immune escape; Immune checkpoint proteins (ICPs); miRNAs.

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